Check out the full UFC 281 lineup below.
Main Card (10 p.m. ET on ESPN+ PPV)
Israel Adesanya vs. Alex Pereira – middleweight title fight
Carla Esparza vs. Zhang Weili – strawweight title fight
Dustin Poirier vs. Michael Chandler
Frankie Edgar vs. Chris Gutierrez
Dan Hooker vs. Claudio Puelles
Preliminary Card (8 p.m. ET on ESPNEWS, ESPN+)
Brad Riddell vs. Renato Moicano
Dominick Reyes vs. Ryan Spann
Erin Blanchfield vs. Molly McCann
Wellington Turman vs. Andre Petroski
Early Prelims (6 p.m. ET on ESPN+, UFC Fight Pass)
Karolina Kowalkiewicz vs. Silvana Gomez Juarez
Michael Trizano vs. Seung Woo Choi
Matt Frevola vs. Ottman Azaitar
Montel Jackson vs. Julio Arce
Carlos Ulberg vs. Nicolae Negumereanu